To change the stat, no.
If I was disconnecting electrical stuff I would most likely disconnect the battery but you can leave all that connected. You can tuck the throttle body and air intake duct out of the way once you’ve released them from the positions with connections intact and get to the stat easily.
I also found better access if I released the air box lid from it’s clips and moved that out of the way.Also whilst you have the throttle body off give it a clean, I gave it a wipe inside with a clean cloth soaked with some WD40, it had some muck built up in there.